Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

The Humanizing Brain is an effort by theological scholars to integrate neuroscience and theological constructs into a cohesive evolutionary and developmental scheme. The primary strength is a developing dialogue between neurodevelopmental theory and process theology. The book's widest appeal should be to theologians exploring religious and spiritual manifestations in the brain and neurosciences. The relatively simplistic science may limit significant usefulness to broad neuroscientific and medical communities, although neuroscientists and sophisticated lay readers with interests and back‐grounds in theology may find (...) The Humanizing Brain quite informative and interesting. (shrink)

Ethical Considerations at the Intersection of Psychiatry and Religion aims to give mental health professionals a conceptual framework for understanding the role of R/S in ethical decision-making and serve as practical guidance for approaching challenging cases. Part I addresses general considerations, including the basis of therapeutic values in a pluralistic context, the nature of theological and psychiatric ethics, spiritual issues arising in diagnosis and treatment, unhealthy and harmful uses of religion, and practical implications of personal spirituality. Part II examines how (...) these considerations apply in specific contexts: inpatient and outpatient, consultation-liaison, child and adolescent, geriatric, disability, forensic, community, international, addiction and disaster and emergency psychiatry, as well as in the work of religious professionals, ethics committees, psychiatric education, and research. Thick descriptions of case examples analyzed using the framework of Jonson and Winslow show the clinical relevance of understanding the contributions of religion and spirituality to patient preferences, quality of life, decision making, and effective treatment. (shrink)

This volume contains the Latin-Italian translation of the Ordinatio Prologue of John Duns Scotus. It is the second volume in the series 'Traditiones: Testi del pensiero tardo-antico, medieval e umanistico', directed by Armando Bisogno. While it is not the first Italian translation of the Ordinatio Prologue, it does offer a rich and detailed introduction that situates Scotus's text in the more general context of his historical milieu, including the effects of the Condemnation of 1277. After a general overview of the (...) life and works of Scotus, including his major positions, the author aids the reader in understanding the significance of Scotus's predecessors... (shrink)

Il disagio dell’estetica, uscito nell’edizione originale francese nel 2004 e in traduzione italiana nel 2009 per ETS a cura di Paolo Godani, è uno dei contributi più incisivi e maturi nella riflessione estetico-politica del filosofo francese Jacques Rancière. Il ripensamento e la ricostruzione della logica del rapporto estetico tra arte e politica è un tema già presente nel precedente percorso critico di Rancière sul “disaccordo” politico e sulla “partizione del sensibile” (LaMésentente. Poli...

This article discusses the concept of the theophóros ánthropos, which belongs to the Patristic tradition, especially to that of Antioch. This concept was widely used in Christology, while the adjective theophóros/deifer was also used for various purposes within the Patristic tradition, with reference to Christ, to the Virgin Mary, to the angels, to good Christians and to human beings inspired by God. The author presents the relevant Patristic texts, then suggests that this concept or model is used in two ways: (...) in an ‘interdisciplinary’ sense, in that it appears in various theological contexts and fields; and in a ‘dialogical’ sense, insofar as the concept provides a bridge to philosophical as well as theological anthropology. In short, theophóros ánthropos is not only an anthropological model for believers, but also a useful concept in dialogue between theology and other disciplines. (shrink)

Lo spettro di un paradosso si aggira nella Galassia Lumière, attraversando tenacemente i sette lemmi chiave (rilocazione, reliquie e icone, assemblage, espansione, ipertopia, display, performance) che scandiscono la struttura interna dell’ultimo libro di Francesco Casetti: come può mantenersi un’identità nel cambiamento? Come può il cinema pur deformandosi nel corso del tempo rimanere sempre lo stesso? Da questo paradossale interrogativo, che innerva il volume dal principio alla fine, sorge s...

Utilizing the metaphor of the palimpsest, this paper looks at layering processes at work in the natural world and human perceptions of it, paying particular attention to the manifestations of the past visible in constructions in and of the landscape. History is made of constant reformations, in which pieces of the past make up the present. The palimpsest offers a useful tool for discussing a trans-temporal landscape. The layers of landscape construction go beyond the literal geological construction, encompassing human pasts (...) and presents as well. Engaging the palimpsestuous layers at work in physical and textual landscape construction allows us to place human endeavours into more expansive notions of temporality. (shrink)

This selection consists of extracts from writings of women concerned solely with the pursuit of abstract ideas, historically contextualized. The texts, for the most part, reflect issues widely debated in their contemporary societies. Extracts from lesser-known writers are also included, providing a diversity of arguments spanning four centuries and including some notable contemporary philosophers.

A leader in the modern commentary on ethics and philosophy, Mary Warnock casts a critical eye over her life and times.

How is hope to be found amid the ethical and political dilemmas of modern life? Writer and philosopher Mary Zournazi brought her questions to some of the most thoughtful intellectuals at work today. She discusses "joyful revolt" with Julia Kristeva, the idea of "the rest of the world" with Gayatri Spivak, the "art of living" with Michel Serres, the "carnival of the senses" with Michael Taussig, the relation of hope to passion and to politics with Chantal Mouffe and Ernesto Laclau. (...) A dozen stimulating minds weigh in with their visions of a better social and political order. The result is a collaboration - of writing, of thinking, and of politics - that demonstrates more clearly than any single-authored project could how ideas encountering one another can produce the vision needed for social change. (shrink)

All religion and much philosophy has been concerned with the contrast between the ephemeral and the eternal. Human beings have always sought ways to overcome time, and to prove that death is not the end. This book consists then in an exploration of certain closely related ideas: personal identity, time, history and our commitment to the future, and the role of imagination in life.

It is believed that the atmosphere in which employees carry out their responsibilities influences whether employees will behave ethically. An important factor contributing to the integrity of the financial reporting process is the tone set by senior management (i.e., the corporate environment). This study was conducted to describe financial accountants'' perceptions of management''s ethical standards. These perceptions are based on both management''s actions and management''s expectations of the employee. This researcher also attempted to identify demographic variables that are related to (...) these perceptions. The results are based on a survey mailed to 400 CPAs who prepare financial reports. Accountants generally perceive management''s conduct as ethical and believe that management expects them to behave ethically. Of particular interest is that respondents have more positive attitudes about management''s expectations of them than they do about management''s own actions in terms of ethical behavior. The majority of respondents reported at least some pressure to achieve short-term performance targets. Management level, industry, size of an organization, and gender were all found to be related to employee perceptions. (shrink)

Fundamental principles : the nature of the dispute -- Types of euthanasia -- Psychiatric assisted suicide -- Neonates -- Incompetent adults -- Human life is sacred -- The slippery slope -- Medical views -- Four methods of easing death and their effect on doctors -- Looking further ahead.

The works of Mary Wollstonecraft (1759-1797) ranged from the early _Thoughts on the Education of Daughters_ to _The Female Reader_, a selection of texts for girls, and included two novels. But her reputation is founded on _A Vindication of the Rights of Woman_ of 1792. This treatise is the first great document of feminism—and is now accepted as a core text in western tradition. It is not widely known that the germ of Wollstonecraft’s great work came out of an earlier (...) and much shorter vindication—A Vindication of the Rights of Men (1790), written in the context of the issues raised by the French Revolution. This edition, which follows the model of other Broadview Editions in including a range of materials that help the reader to see the work in the context of its era out of which it emerged, is arranged chronologically, opening with Wollstonecraft’s “other vindication.” It also includes a wide range of other documents in appendices, as well as a comprehensive and authoritative introduction, chronology, and full index. (shrink)

BRENTANO'S APPROPRIATION OF THE Scholastic notion of intentionality, and of what Brentano called "the intentional (or mental) inexistence of an object," was early on exploited in a reading of Kant's theory of objects and appearances. Apparently the first systematic attempt was undertaken by Hans Vaihinger. However, Vaihinger's is radically different from more recent intentionalist readings of Kant. Albeit not in every respect, I propose that a return to this aspect of Vaihinger's approach supports a rewarding advance on such readings. After (...) a general introduction, I survey three instances of the latter—Prauss, Pereboom, and Sellars—in section 2 (and comment on some others in notes throughout). In sections 3 and 4, I then turn to Vaihinger's approach. (shrink)